منابع مشابه
SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation.
Primary microcephaly is an autosomal recessive disorder characterized by marked reduction in human brain size. Microcephalin (MCPH1), one of the genes mutated in primary microcephaly, plays an important role in DNA damage checkpoint control and mitotic entry. Additionally, MCPH1 ensures the proper temporal activation of chromosome condensation during mitosis, by acting as a negative regulator o...
متن کاملThe nuclear oncogene SET controls DNA repair by KAP1 and HP1 retention to chromatin.
Cells experience damage from exogenous and endogenous sources that endanger genome stability. Several cellular pathways have evolved to detect DNA damage and mediate its repair. Although many proteins have been implicated in these processes, only recent studies have revealed how they operate in the context of high-ordered chromatin structure. Here, we identify the nuclear oncogene SET (I2PP2A) ...
متن کاملA RELATION BETWEEN THE CATEGORIES Set * , SetT, Set AND SetT
In this article, we have shown, for the add-point monad T, thepartial morphism category Set*is isomorphic to the Kleisli category SetT. Alsowe have proved that the category, SetT, of T-algebras is isomorphic to thecategory Set of pointed sets. Finally we have established commutative squaresinvolving these categories.
متن کاملSET oncogene is upregulated in pediatric acute lymphoblastic leukemia.
AIMS AND BACKGROUND The SET gene is a target of chromosomal translocations in acute leukemia and encodes a widely expressed multifunctional phosphoprotein. It has been shown that SET is upregulated in BCR-ABL1-positive cell lines, patient-derived chronic myeloid leukemia CD34-positive cells, and some solid tumors. METHODS AND STUDY DESIGN We determined the expression level of SET in 59 pediat...
متن کاملNuclear masses set bounds on quantum chaos.
It has been suggested that chaotic motion inside the nucleus may significantly limit the accuracy with which nuclear masses can be calculated. Using a power spectrum analysis we show that the inclusion of additional physical contributions in mass calculations, through many-body interactions or local information, removes the chaotic signal in the discrepancies between calculated and measured mas...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2013
ISSN: 1768-3262
DOI: 10.4267/2042/51874